Yanagida H, Corssen G
Anesthesiology. 1981 Nov;55(5):515-9. doi: 10.1097/00000542-198111000-00006.
Beta-endorphin-like immunoreactivity was determined in the plasma of twenty patients suffering from hypoxia of various etiologies and in twenty healthy adult volunteers who served as controls. Mean beta-endorphin-like immunoreactivity in the hypoxic patients was 53.2 +/- 5.5 (SEM) pg/ml, as compared to the volunteer subjects in whom the mean level was 6.2 +/- 1.9 pg/ml (P less than 0.01). Significant negative correlations were present between both arterial pH (r = -0.85; P less than 0.01) and arterial PO2 (r = -0.80; P less than 0.01) and beta-endorphin-like immunoreactivity. These findings seem to lend support to the hypothesis that hypoxia and acidosis represent stressful conditions which may stimulate the release of beta-endorphin in humans.
在20名患有各种病因缺氧的患者以及20名作为对照的健康成年志愿者的血浆中测定了β-内啡肽样免疫反应性。缺氧患者的平均β-内啡肽样免疫反应性为53.2±5.5（SEM）pg/ml，而志愿者受试者的平均水平为6.2±1.9 pg/ml（P<0.01）。动脉血pH值（r = -0.85；P<0.01）和动脉血氧分压（r = -0.80；P<0.01）与β-内啡肽样免疫反应性之间均存在显著的负相关。这些发现似乎支持了以下假设，即缺氧和酸中毒代表应激状态，可能会刺激人类体内β-内啡肽的释放。
