铁从转铁蛋白向铁蛋白的转移由多磷酸盐化合物介导。

Iron transfer form transferrin to ferritin mediated by polyphosphate compounds.

作者信息

Konopka K, Mareschal J C, Crichton R R

出版信息

Biochim Biophys Acta. 1981 Nov 5;677(3-4):417-23. doi: 10.1016/0304-4165(81)90255-5.

Abstract

We have studied iron transfer from transferrin to ferritin in the presence of ATP, GTP, ADP, AMP and 2,3-diphosphoglycerate. These compounds, with the exception of AMP, can release iron from transferrin at pH 7.4 and form a stable Fe(III)-phosphate complex. From these complexes, only a limited number of Fe(III) atoms can be incorporated into ferritin. Ascorbate enhances iron transfer from transferrin to ferritin at the beginning of the process but subsequently inhibits further iron deposition in ferritin.

摘要

我们研究了在ATP、GTP、ADP、AMP和2,3-二磷酸甘油酸存在的情况下，铁从转铁蛋白向铁蛋白的转移。除AMP外，这些化合物在pH 7.4时可从转铁蛋白中释放铁，并形成稳定的Fe(III)-磷酸盐复合物。从这些复合物中，只有有限数量的Fe(III)原子能够掺入铁蛋白中。在该过程开始时，抗坏血酸可增强铁从转铁蛋白向铁蛋白的转移，但随后会抑制铁在铁蛋白中的进一步沉积。