Anghileri L J, Thouvenot P
Biophysics Laboratory, University of Nancy, France.
Anticancer Res. 1997 Jul-Aug;17(4A):2529-33.
The study of iron uptake from low molecular weight complexes by Ehrlich carcinoma cells shows concentration-dependence, and ATP increases the iron uptake from citrate and lactate complexes. Blood proteins can act as inhibitors, and deferoxamine chelation of cell-bound iron complex indicates that the percentage of iron penetrating the cell is about the same for a wide range of iron complex concentrations in the incubation medium (about 5% for ferric lactate). Ascorbic acid increases iron uptake and simultaneously decreases lipid peroxidation. Electrophoresis shows a very high iron transfer from ferric lactate to ATP, and to a lesser extent to ADP and AMP. In the pathological evolution of iron overload to a neoplasia, the probable involvement of an iron exchange between iron complexes from non-transferrin-bound iron of plasma and ATP is discussed.
对艾氏腹水癌细胞从低分子量复合物摄取铁的研究表明存在浓度依赖性，并且ATP可增加从柠檬酸盐和乳酸盐复合物中的铁摄取。血液蛋白可作为抑制剂，去铁胺对细胞结合铁复合物的螯合表明，对于孵育培养基中广泛的铁复合物浓度，穿透细胞的铁的百分比大致相同（乳酸铁约为5%）。抗坏血酸增加铁摄取并同时降低脂质过氧化。电泳显示从乳酸铁到ATP有非常高的铁转移，到ADP和AMP的程度较小。在铁过载向肿瘤形成的病理演变中，讨论了血浆中非转铁蛋白结合铁的铁复合物与ATP之间铁交换的可能参与情况。
