恶性高热中骨骼肌腺苷酸环化酶水平较高。
High skeletal muscle adenylate cyclase in malignant hyperthermia.
作者信息
Willner J H, Cerri C G, Wood D S
出版信息
J Clin Invest. 1981 Nov;68(5):1119-24. doi: 10.1172/jci110355.
Abstract
Malignant hyperthermia occurs in humans with several congenital myopathies, usually in response to general anesthesia. Commonly, individuals who develop this syndrome lack symptoms of muscle disease, and their muscle lacks specific pathological changes. A biochemical marker for this myopathy has not previously been available; we found activity of adenylate cyclase and content of cyclic AMP to be abnormally high in skeletal muscle. Secondary modification of protein phosphorylation could explain observed abnormalities of phosphorylase activation and sarcoplasmic reticulum function.
摘要
恶性高热发生于患有几种先天性肌病的人类，通常是对全身麻醉的反应。一般来说，出现这种综合征的个体没有肌肉疾病的症状，其肌肉也没有特定的病理变化。此前一直没有这种肌病的生化标志物；我们发现骨骼肌中腺苷酸环化酶的活性和环磷酸腺苷的含量异常高。蛋白质磷酸化的继发性修饰可以解释观察到的磷酸化酶激活和肌浆网功能异常。
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本文引用的文献
1
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J Biol Chem. 1951 Nov;193(1):265-75.
2
Anaesthetic deaths in a family.家族中的麻醉死亡病例
Br J Anaesth. 1962 Jun;34:395-6. doi: 10.1093/bja/34.6.395.
3
Circulating adrenaline and noradrenaline during diethyl ether anaesthesia in man.人体在乙醚麻醉期间循环中的肾上腺素和去甲肾上腺素。
Clin Sci. 1957 May;16(2):377-87.
4
Assay of adenylate cyclase in homogenates of control and Duchenne human skeletal muscle.
Clin Chim Acta. 1981 Apr 9;111(2-3):133-46. doi: 10.1016/0009-8981(81)90180-7.
5
Phosphorylation of a 100 000 dalton component and its relationship to calcium transport in sarcoplasmic reticulum from rabbit skeletal muscle.
Biochim Biophys Acta. 1980 Apr 3;628(4):438-50. doi: 10.1016/0304-4165(80)90393-1.
6
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Can Anaesth Soc J. 1969 Mar;16(2):89-98. doi: 10.1007/BF03005788.
7
Malignant hyperthermia: an investigation of five patients.恶性高热：5例患者的调查
Can Anaesth Soc J. 1973 Jul;20(4):431-67. doi: 10.1007/BF03026208.
8
Effects of isoflurane and halothane on contractility and the cyclic 3', 5'-adenosine monophosphate system in the rat aorta.
Anesthesiology. 1974 Feb;40(2):162-7. doi: 10.1097/00000542-197402000-00013.
9
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J Biol Chem. 1972 May 10;247(9):2949-58.
10
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