O'Brien B M, Das S K, Franklin J D, Morrison W A
Plast Reconstr Surg. 1981 Dec;68(6):922-6. doi: 10.1097/00006534-198112000-00013.
Lymphangiography, using oily radiopaque Lipiodol Ultra Fluid has been shown to increase lymphedema in one-third of the patients with obstructive lymphedema and to cause lymphatic obliteration (demonstrated histologically). No effective element has been observed, although subclinical infection could not be ruled out. Allergy is another possible contributor, but the evidence from this series suggests that Lipiodol may act as a direct irritant when it is not rapidly cleared, as in the case of obstructive lymphedema, and proceed to obliteration of the residual lymphatics. On the basis of these findings, elective routine preoperative lymphangiography for lymphedema is considered strongly inadvisable.
淋巴管造影术，使用油性不透射线的超液态碘油，已被证明会使三分之一的阻塞性淋巴水肿患者的淋巴水肿加重，并导致淋巴管闭塞（组织学证实）。虽然不能排除亚临床感染，但未观察到有效因素。过敏是另一个可能的因素，但该系列研究的证据表明，碘油在未像阻塞性淋巴水肿那样迅速清除时，可能作为一种直接刺激物，进而导致残留淋巴管闭塞。基于这些发现，强烈不建议对淋巴水肿患者进行选择性常规术前淋巴管造影。
