Iliescu R, Muţiu A, Sahnazarov N, Mihalache O, Repanovici R, Löber G, Popa L M
Virologie. 1981 Jul-Sep;32(3):217-23.
The effect of violamycin BI (VBI) was investigated in different cell substrates, infected or not with herpes simplex virus type 1 (HSV-1), strains VR3 and Rapp-1. The cytotoxic dose of VBI was established in calf kidney and human embryo cell cultures. Low drug concentrations induced moderate cytotoxic changes, allowing the study of the cells for 4-6 days. The action of VBI on HSV-1 was evident mostly in the early phases of the virus multiplication cycle. The antiviral effect of VBI was due both to the direct action of the drug on HSV and to its interaction with the nucleic acids of the host cells supporting HSV multiplication in their nuclei.
研究了维奥拉霉素BI（VBI）在不同细胞底物中的作用，这些细胞底物感染或未感染1型单纯疱疹病毒（HSV-1）的VR3和Rapp-1毒株。在小牛肾和人胚胎细胞培养物中确定了VBI的细胞毒性剂量。低药物浓度引起中度细胞毒性变化，使得能够对细胞进行4至6天的研究。VBI对HSV-1的作用主要在病毒增殖周期的早期阶段明显。VBI的抗病毒作用既归因于药物对HSV的直接作用，也归因于其与支持HSV在细胞核中增殖的宿主细胞核酸的相互作用。
