钙拮抗作用并非一帆风顺。
Calcium antagonism is no rose.
作者信息
Winquist R J, Webb R C, Bohr D F
出版信息
Fed Proc. 1981 Dec;40(14):2852-4.
PMID:6273236
Abstract
Much remains to be defined about the mechanism of action of calcium entry blockers. The diversity of their pharmacological actions reflects the many effects of the calcium ions which they block. The observation that D-600 decreases myogenic tone in the rabbit basilar artery, whereas it increases this tone in the facial vein, is cited as an example of this diversity.
摘要
关于钙通道阻滞剂的作用机制仍有许多有待明确之处。它们药理作用的多样性反映了它们所阻断的钙离子的多种效应。D - 600降低兔基底动脉的肌源性张力，而增加面静脉的肌源性张力，这一观察结果被引为例证来说明这种多样性。
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