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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Kharasch E D, Mellow A M, Silinsky E M

J Physiol. 1981 May;314:255-63. doi: 10.1113/jphysiol.1981.sp013705.

The effects of intracellular application of Ca and Mg ions on evoked acetylcholine secretion at frog motor nerve terminals were studied. Ca and Mg were applied to the nerve-ending cytoplasm using liposomes as a vehicle. 2. Under conditions in which intracellular application of Ca produced many-fold increased in evoked acetylcholine release. 3. When Mg was applied to the nerve-ending cytoplasm concurrently with Ca, acetylcholine release was further increased above the level produced by introducing Ca alone. 4. The results suggest that intracellular Mg does not antagonize depolarization-secretion coupling and that antagonism of transmitter release by extracellular Mg occurs only at the external surface of the nerve ending.

研究了细胞内施加钙和镁离子对青蛙运动神经末梢诱发乙酰胆碱分泌的影响。使用脂质体作为载体将钙和镁施加到神经末梢细胞质中。2. 在细胞内施加钙使诱发的乙酰胆碱释放增加数倍的条件下。3. 当镁与钙同时施加到神经末梢细胞质中时，乙酰胆碱释放进一步增加，高于单独引入钙所产生的水平。4. 结果表明，细胞内镁并不拮抗去极化-分泌偶联，细胞外镁对递质释放的拮抗作用仅发生在神经末梢的外表面。

Kharasch E D, Mellow A M, Silinsky E M

J Physiol. 1981 May;314:255-63. doi: 10.1113/jphysiol.1981.sp013705.

The effects of intracellular application of Ca and Mg ions on evoked acetylcholine secretion at frog motor nerve terminals were studied. Ca and Mg were applied to the nerve-ending cytoplasm using liposomes as a vehicle. 2. Under conditions in which intracellular application of Ca produced many-fold increased in evoked acetylcholine release. 3. When Mg was applied to the nerve-ending cytoplasm concurrently with Ca, acetylcholine release was further increased above the level produced by introducing Ca alone. 4. The results suggest that intracellular Mg does not antagonize depolarization-secretion coupling and that antagonism of transmitter release by extracellular Mg occurs only at the external surface of the nerve ending.

研究了细胞内施加钙和镁离子对青蛙运动神经末梢诱发乙酰胆碱分泌的影响。使用脂质体作为载体将钙和镁施加到神经末梢细胞质中。2. 在细胞内施加钙使诱发的乙酰胆碱释放增加数倍的条件下。3. 当镁与钙同时施加到神经末梢细胞质中时，乙酰胆碱释放进一步增加，高于单独引入钙所产生的水平。4. 结果表明，细胞内镁并不拮抗去极化-分泌偶联，细胞外镁对递质释放的拮抗作用仅发生在神经末梢的外表面。