Whang-Peng J, Kao-Shan C S, Lee E C, Bunn P A, Carney D N, Gazdar A F, Minna J D
Science. 1982 Jan 8;215(4529):181-2. doi: 10.1126/science.6274023.
A specific, acquired chromosomal abnormality (deletion 3p) has been found in at least one chromosome 3 in 100 percent of the metaphases in 12 of 12 cell lines cultured from human small-cell lung cancer tissue and in 2-day tumor culture specimens from three patients. Analysis of the shortest region of overlap shows the deletion to be 3p(14-23). This specific change was not seen in five of five lung cancer cell lines other than small-cell lung cancer or in two lymphoblastoid lines cultured from cells of small-cell lung cancer patients whose tumors had the 3p deletion.
在从人小细胞肺癌组织培养的12个细胞系中的12个以及来自3例患者的2天肿瘤培养标本的所有中期细胞中，至少一条3号染色体上均发现了一种特定的、后天性染色体异常（3p缺失）。重叠最短区域分析显示该缺失为3p(14 - 23)。在除小细胞肺癌之外的5个肺癌细胞系或从肿瘤有3p缺失的小细胞肺癌患者细胞培养的2个淋巴母细胞系中未见到这种特定变化。
