Sarateanu D E, Allerdist H, Ehrengut W
Immun Infekt. 1978 Feb;6(1):33-7.
The authors studied the seroconversion of 307 children, 1-11 years old, induced by Mumpsvax (136 children) and a bivalent mumps-measles vaccine (strain Jeryl Lynn/strain Moraten; 171 vaccines) by the HI-test. The seroconversion induced by the measles component of the bivalent vaccine covered 96.3% of the seronegatives prior to immunization. The comparable values for mumps antibodies were lower (Mumpsvax:80.6%; bivlant vaccine: 82.2%). An increase in titer in seropositive children was obtained in 57.1% after immunization with Mumpsvax and in 50.8% with the bivalent vaccine. Comparative studies to investigate the sensitivity of the HI-test versus the neutralisation test (NT) showed the greater accuracy of the latter. Before the vaccination with Mumpsvax, only 26.6% of 60 sera studied were found to be seronegative, whilst the NT gave a more reliable figure (55%). Similar data were found in 62 sera before immunization with the bivalent vaccine (HI-test: 33.8%; NT:66.1% seronegative). The seroconversion rates were slightly higher when the NT had been used: 75.6% (bivalent) and 81.8% (monovalent vaccine) versus 75.6% and 75%, respectively, by the HI-test.
作者通过血凝抑制试验（HI试验）研究了307名1至11岁儿童接种腮腺炎疫苗（Mumpsvax，136名儿童）和二价腮腺炎-麻疹疫苗（杰里尔·林恩株/莫拉坦株；171名儿童）后的血清转化情况。二价疫苗中麻疹成分诱导的血清转化覆盖了免疫前96.3%的血清阴性儿童。腮腺炎抗体的相应数值较低（腮腺炎疫苗：80.6%；二价疫苗：82.2%）。接种腮腺炎疫苗后，57.1%的血清阳性儿童抗体滴度升高，接种二价疫苗后这一比例为50.8%。比较HI试验与中和试验（NT）敏感性的研究表明，后者的准确性更高。在接种腮腺炎疫苗前，研究的60份血清中只有26.6%被发现为血清阴性，而NT得出的数字更可靠（55%）。在接种二价疫苗前的62份血清中也发现了类似的数据（HI试验：33.8%；NT：66.1%血清阴性）。使用NT时血清转化率略高：二价疫苗为75.6%，单价疫苗为81.8%，而HI试验分别为75.6%和75%。
