Vlahov V, Zafirov D
Acta Physiol Pharmacol Bulg. 1981;7(2):61-8.
The experiments were carried out on cats anesthetized with chloralose, curarized and artificially ventilated. The local cortical CBF was recorded by the thermoclearance technique. The cAMP level in the grey matter of the cerebral cortex and the arterial blood pressure, as well as the arterial blood gas content were measured. Increased concentration of CO2 in the inspired mixture (paCO2 = 79.8 +/- 8.5 mm Hg) caused an enhancement of CBF, without inducing changes in the cAMP level (1.71 +/- 0.07 nmoles/g wet weight). Increasing the PaCO2 up to 184.42 +/- 12.3 mm Hg produced neither a further increase of CBF, nor a rise of cAMP level. Adrenaline injected into the cerebral ventricles led to an increase of cAMP up to 4.42 +/- 0.7 nmoles/g without changing CBF. Saline in the same volume increased cAMP level to a smaller degree (2.71 +/- 0.26 nmoles/g). No changes in CBF were registered. Dibutyryl cAMP, cAMP and adenosine injected into a. lingualis did not significantly change the CBF.
实验在用氯醛糖麻醉、箭毒化并人工通气的猫身上进行。采用热清除技术记录局部皮质脑血流量（CBF）。测量大脑皮质灰质中的环磷酸腺苷（cAMP）水平、动脉血压以及动脉血气含量。吸入混合气中二氧化碳浓度升高（动脉血二氧化碳分压[paCO2]=79.8±8.5毫米汞柱）导致CBF增加，而cAMP水平无变化（1.71±0.07纳摩尔/克湿重）。将PaCO2升高至184.42±12.3毫米汞柱既未使CBF进一步增加，也未使cAMP水平升高。向脑室注射肾上腺素导致cAMP升高至4.42±0.7纳摩尔/克，而CBF无变化。相同体积的生理盐水使cAMP水平升高程度较小（2.71±0.26纳摩尔/克）。未记录到CBF的变化。向舌动脉注射二丁酰cAMP、cAMP和腺苷未显著改变CBF。
