人体内α-肾上腺素能受体的内源性激动剂调节

Endogenous agonist regulation of alpha-adrenoceptors in man.

Davies I B, Sudera D, Sever P S

Clin Sci (Lond). 1981 Dec;61 Suppl 7:207s-210s. doi: 10.1042/cs061207s.

Abstract

Plasma noradrenaline concentrations and platelet alpha-receptor properties were measured in 14 normal subjects, five phaeochromocytoma patients and nine patients with multiple system atrophy and sympathetic nervous system degeneration (MSA). 2. Plasma noradrenaline concentrations in phaeochromocytoma were 10- to 20-times greater than those of normal subjects and one-fifth to one-half of normal in MSA patients. 3. Platelet alpha-receptor numbers were increased in MSA and decreased in phaeochromocytoma compared with normal subjects. There was no change in platelet alpha-receptor affinity in either group. 4. The inverse relationship between alpha-receptor numbers and plasma noradrenaline concentrations may reflect regulation of alpha-receptor number by endogenous adrenergic agonist concentrations in man.

摘要

对14名正常受试者、5名嗜铬细胞瘤患者和9名多系统萎缩伴交感神经系统变性（MSA）患者测量了血浆去甲肾上腺素浓度和血小板α受体特性。2. 嗜铬细胞瘤患者的血浆去甲肾上腺素浓度比正常受试者高10至20倍，而MSA患者的血浆去甲肾上腺素浓度为正常受试者的五分之一至二分之一。3. 与正常受试者相比，MSA患者的血小板α受体数量增加，嗜铬细胞瘤患者的血小板α受体数量减少。两组患者的血小板α受体亲和力均无变化。4. α受体数量与血浆去甲肾上腺素浓度之间的负相关关系可能反映了人体内源性肾上腺素能激动剂浓度对α受体数量的调节。