溴隐亭对自发性高血压大鼠血压及血浆β-内啡肽的影响。

Effects of bromocriptine on blood pressure and plasma beta-endorphin in spontaneously hypertensive rats.

Hutchinson J S, Di Nicolantonio R, Lim A, Clements J, Funder J W

Clin Sci (Lond). 1981 Dec;61 Suppl 7:343s-345s. doi: 10.1042/cs061343s.

Abstract

Immunoreactive beta-endorphin (IR-beta EP) was two- to three-fold higher in pituitary neuro-intermediate lobes (N-IL) of spontaneously hypertensive rats (SHR) than of normotensive Wistar--Kyoto (NT-WKY) controls. 2. Plasma levels of IR-beta EP were lower in SHR than in NT-WKY rats. 3. Intravenous injections of morphine lowered blood pressure of both SHR and NT-WKY rats to the same level; naloxone restored blood pressure of both groups to pre-morphine values. 4. Infusion of bromocriptine in SHR for 1 week lowered blood pressure and N-IL IR-beta EP concentration. 5. These results confirm and extend postulated dopaminergic defect in this model of hypertension.

摘要

自发性高血压大鼠（SHR）垂体神经中间叶（N-IL）中免疫反应性β-内啡肽（IR-βEP）比正常血压的Wistar-Kyoto（NT-WKY）对照大鼠高两到三倍。2. SHR血浆中IR-βEP水平低于NT-WKY大鼠。3. 静脉注射吗啡使SHR和NT-WKY大鼠的血压降至相同水平；纳洛酮使两组血压恢复到吗啡注射前的值。4. 向SHR输注溴隐亭1周可降低血压和N-IL中IR-βEP浓度。5. 这些结果证实并扩展了该高血压模型中多巴胺能缺陷的假设。