Ward H E, Jones R L, King E G, Sproule B J, Fortune R L
Chest. 1982 Jan;81(1):11-5. doi: 10.1378/chest.81.1.11.
An intraluminal carcinoid tumor obstructing the left mainstem bronchus produced hypoxemia through alteration in ventilation/perfusion matching. Studies of regional lung function using 133-xenon (133Xe) and a multiprobe computerized instrumentation system documented a reduction of perfusion to 22 percent and ventilation to 6 percent of the total. There was negligible washout of intravenously injected 133Xe from the left lung consistent with air trapping. Four days after left mainstem bronchial sleeve resection, perfusion, ventilation and washout of injected xenon had significantly improved and by four months postresection, all measurements were virtually normal, although complete restoration of perfusion in relation to ventilation was delayed. Regional lung function studied with a multiprobe system in this patient provided a clinical model for the study of ventilation and perfusion inter-relationships in large airway obstruction and demonstrated that a prolonged time may be required for return of perfusion to normal.
一例腔内类癌肿瘤阻塞左主支气管，通过通气/灌注匹配改变导致低氧血症。使用133氙（133Xe）和多探头计算机仪器系统对局部肺功能进行的研究表明，灌注减少至总量的22%，通气减少至总量的6%。静脉注射的133Xe从左肺的洗脱可忽略不计，这与气体潴留一致。左主支气管袖状切除术后四天，注入氙的灌注、通气和洗脱明显改善，到切除术后四个月，所有测量值几乎正常，尽管灌注与通气的完全恢复有所延迟。用多探头系统对该患者进行的局部肺功能研究为研究大气道阻塞时通气与灌注的相互关系提供了一个临床模型，并表明灌注恢复正常可能需要较长时间。
