Cros G H, Serrano J J, McNeill J H
Eur J Pharmacol. 1981 Aug 27;74(1):95-9. doi: 10.1016/0014-2999(81)90328-9.
Trypsin (10(-6)M produced a positive inotropic and chronotropic effect in left and right atria respectively and an increase in cyclic AMP. The effects were blocked by aprotinine while propranolol, phentolamine, promethazine and cimetidine and reserpine pretreatment did not alter trypsin activity. Trypsin effects were potentiated by RO 20,1724, a phosphodiesterase inhibitor. The cardiac effects of trypsin may be due to increase in cyclic AMP and are in agreement with previous work indicating that trypsin can activate cardiac adenylate cyclase.
胰蛋白酶（10⁻⁶M）分别在左右心房产生正性变力和变时作用，并使环磷酸腺苷（cAMP）增加。这些作用被抑肽酶阻断，而普萘洛尔、酚妥拉明、异丙嗪、西咪替丁和利血平预处理并未改变胰蛋白酶的活性。磷酸二酯酶抑制剂RO 20,1724可增强胰蛋白酶的作用。胰蛋白酶对心脏的作用可能是由于cAMP增加，这与之前表明胰蛋白酶可激活心脏腺苷酸环化酶的研究结果一致。
