Kursh E D, Klein L, Persky L, Schmitt J, Kayal S
Invest Urol. 1978 Jan;15(4):328-30.
The effect of nutrition on the healing capacity of uremic rats was investigated. Wound tensile strenth and the amount of collagen formation in polyvinyl sponges implanted subcutaneously were compared in a group of uremic rats and a group of nonuremic rats parallel-fed an identical diet and caloric intake. Wound tensile strength in the parafed rats closely and significantly approximated that in the uremic snimals conpared to the stronger wounds in the controls. A correlation was also noted for collagen accumulation in the uremic and parafed groups. This experiment lends further evidence to support the theory that the mechanism of action for the shown poor healing associated with uremia is based on the poor state of nutrition in the uremic animal.
研究了营养对尿毒症大鼠愈合能力的影响。在一组尿毒症大鼠和一组非尿毒症大鼠中，比较了皮下植入聚乙烯海绵后的伤口抗张强度和胶原蛋白形成量，这两组大鼠平行喂养相同的饮食和热量摄入。与对照组较强的伤口相比，随意进食大鼠的伤口抗张强度与尿毒症动物的伤口抗张强度密切且显著接近。在尿毒症组和随意进食组中也观察到胶原蛋白积累的相关性。该实验进一步证明了支持以下理论的证据：与尿毒症相关的愈合不良的作用机制是基于尿毒症动物营养状况不佳。
