Hsu C H, Kurtz T W, Rosenzweig J, Weller J M
Invest Urol. 1978 Jan;15(4):348-51.
Impairment of renal function was noted after release of 24 hr of unilateral (UUO) and bilateral (BUO) ureteral obstruction. After release of obstruction fractional sodium excretion was identical in both obstructed and intact kidney of UUO rats, whereas massive natriuresis occurred in BUO rats. Renal blood flow in BUO rats, determined by the microsphere method after released of 24 h of obstruction, was approximately 60 per cent of control values. Mean renal blood flow of the obstructed kidney of UUO rats after release of obstruction was 78 per cent of the mean renal blood flow of the contralateral unobstructed kidney. No redistribution of intrarenal blood flow was noted in UUO and BUO rats. Filtration fractions of obstructed kidneys from BUO and UUO rats after release of obstruction were lower than those of controls, suggesting that preglomerular vasoconstriction is primarily involved in the reduction of glomerular filtration rate.
在单侧（UUO）和双侧（BUO）输尿管梗阻24小时解除后，观察到肾功能受损。梗阻解除后，UUO大鼠梗阻侧和未梗阻侧肾脏的钠排泄分数相同，而BUO大鼠则出现大量利尿。通过微球法在梗阻24小时解除后测定的BUO大鼠肾血流量约为对照值的60%。梗阻解除后，UUO大鼠梗阻侧肾脏的平均肾血流量是对侧未梗阻肾脏平均肾血流量的78%。在UUO和BUO大鼠中未观察到肾内血流重新分布。梗阻解除后，BUO和UUO大鼠梗阻肾脏的滤过分数低于对照组，提示肾小球前血管收缩是肾小球滤过率降低的主要原因。
