Goldfarb A H, Kendrick Z V
J Appl Physiol Respir Environ Exerc Physiol. 1981 Dec;51(6):1539-42. doi: 10.1152/jappl.1981.51.6.1539.
The purpose of this investigation was to determine whether adenosine 3',5'-cyclic monophosphate (cAMP) content is increased in vivo in the heart as a result of exercise at a time when there is rapid cardiac glycogen utilization. Rats were run to exhaustion on a treadmill for a period of 164.5 +/- 9.5 min. Blood norepinephrine and epinephrine were significantly elevated approximately 2.5-fold above resting levels at the end of the treadmill run. Myocardial glycogen was reduced by 54.7% at exhaustion compared with control values. Myocardial cAMP was significantly elevated 88% above control levels as a result of the run. Associated with the depletion of myocardial glycogen and the elevation of cAMP was an activation of phosphorylase to its a form. These data suggest that myocardial glycogen metabolism during exercise is, in part, mediated by hormonal influences that are associated with increases in cAMP.
本研究的目的是确定在心脏糖原快速消耗时，运动是否会导致体内3',5'-环磷酸腺苷（cAMP）含量增加。大鼠在跑步机上跑至力竭，持续时间为164.5±9.5分钟。跑步机运动结束时，血液中的去甲肾上腺素和肾上腺素显著升高，约为静息水平的2.5倍。与对照组相比，力竭时心肌糖原减少了54.7%。运动导致心肌cAMP显著升高，比对照水平高88%。伴随着心肌糖原的消耗和cAMP的升高，磷酸化酶被激活为a型。这些数据表明，运动期间心肌糖原代谢部分是由与cAMP增加相关的激素影响介导的。
