Gennari C, Loré F, Galli M, D'Amore I D, Francini G
J Endocrinol Invest. 1981 Jul-Sep;4(3):323-6. doi: 10.1007/BF03349451.
In a group of healthy young men and women the daily urinary excretion of cyclic adenosine 3', 5'-monophosphate (cAMP), calcium, hydroxyproline and the renal threshold phosphate concentration were evaluated at monthly intervals during 1 yr. A significant seasonal variation in cAMP urinary excretion was demonstrated, with a maximum occurring in spring and a minimum in winter. A clear annual rhythm was also observed when the other above parameters were considered. These findings are of importance in the interpretation of urinary cAMP values in clinical situations, and in the study of bone metabolism.
在一组健康的年轻男性和女性中，对1年期间每月的环磷腺苷（cAMP）、钙、羟脯氨酸每日尿排泄量以及肾阈磷酸盐浓度进行了评估。结果显示，cAMP尿排泄量存在显著的季节性变化，春季最高，冬季最低。当考虑上述其他参数时，也观察到了明显的年度节律。这些发现对于临床情况下尿cAMP值的解释以及骨代谢研究具有重要意义。
