Takahashi T
Hokkaido Igaku Zasshi. 1981 Mar;56(2):105-31.
Weanling rats fed a diet containing elemental tellurium became paralyzed of their hind legs based on segmental demyelination of the sciatic nerves. Recovery from the paralysis and remyelination took place despite continued receiving of the diet. The author could divide the process of demyelination and remyelination into four stages (Stage I-IV). The earliest changes were observed in the Schwann cell cytoplasm in which the Golgi complex revealed shrinkage, fragmentation and vacuolation. These changes soon involved the endoplasmic reticulum (Stage I). Degenerative changes of the Golgi complex and the endoplasmic reticulum were considered to disturb the active Schwann cell metabolism inhibiting the synthesis and maintenance of the myelin, resulted in disintegration and destruction of the myelin sheath (Stage II). Schwann cells proliferated around the demyelinated axons extending numerous elongated processes (Stage III). When remyelination began, only one simple shaped Schwann cell was associated with the axon. Remyelinated fibers were generally small in size, which was considered to be related to the formation of the short segments as well as to the Schwann cell proliferation (Stage IV).
喂食含元素碲饮食的断奶大鼠，基于坐骨神经的节段性脱髓鞘，其后腿出现麻痹。尽管持续喂食该饮食，大鼠仍从麻痹状态恢复并发生了髓鞘再生。作者可将脱髓鞘和髓鞘再生过程分为四个阶段（阶段I-IV）。最早的变化见于施万细胞胞质，其中高尔基体出现萎缩、碎片化和空泡化。这些变化很快累及内质网（阶段I）。高尔基体和内质网的退行性变化被认为扰乱了施万细胞的活跃代谢，抑制了髓磷脂的合成和维持，导致髓鞘崩解和破坏（阶段II）。施万细胞在脱髓鞘轴突周围增殖，伸出许多细长的突起（阶段III）。当髓鞘再生开始时，只有一个形态简单的施万细胞与轴突相关。再生髓鞘化的纤维通常尺寸较小，这被认为与短节段的形成以及施万细胞增殖有关（阶段IV）。
