一种甲硫氨酸脑啡肽类似物和纳洛酮输注对肢端肥大症患者垂体前叶激素分泌的影响。

Effects of a Met-enkephalin analogue and naloxone infusion on anterior pituitary hormone secretion in acromegaly.

作者信息

Delitala G, Giusti M, Borsi L, Devilla L, Mazzochi G, Lotti G, Giordano G

出版信息

Horm Res. 1981;15(2):88-98. doi: 10.1159/000179438.

Abstract

The effect of a long-acting analogue of Met-enkephalin (Damme) and naloxone on anterior pituitary hormone secretion has been investigated in 14 acromegalic patients. Damme produced a progressive fall in circulating LH and cortisol and stimulated prolactin release in normoprolactinaemic patients. Naloxone infusion significantly stimulated gonadotrophin and cortisol secretion without modifying basal prolactin release both in normo-and hyperprolactinamic patients. GH levels remained unchanged during naloxone and Damme infusion. The data suggest that endogenous opiate receptors do not play a major role in modulating GH hypersecretion in acromegaly.

摘要

已在14例肢端肥大症患者中研究了甲硫氨酸脑啡肽长效类似物（达美）和纳洛酮对垂体前叶激素分泌的影响。达美使正常催乳素血症患者的循环促黄体生成素（LH）和皮质醇逐渐下降，并刺激催乳素释放。在正常和高催乳素血症患者中，输注纳洛酮均显著刺激促性腺激素和皮质醇分泌，而不改变基础催乳素释放。在输注纳洛酮和达美的过程中，生长激素（GH）水平保持不变。数据表明，内源性阿片受体在肢端肥大症中调节GH分泌过多方面不发挥主要作用。