小鼠实验性副流感病毒感染：由副流感3病毒变种引起的小鼠致命疾病及胸腺和脾脏萎缩
Experimental parainfluenzavirus infection in mice: fatal illness with atrophy of thymus and spleen in mice caused by a variant of parainfluenza 3 virus.
作者信息
Shibuta H, Adachi A, Kanda T, Matumoto M
出版信息
Infect Immun. 1982 Feb;35(2):437-41. doi: 10.1128/iai.35.2.437-441.1982.
Abstract
Intracerebral inoculation of the YN strain of parainfluenza 3 virus was found to induce an acute fatal illness characterized by marked thymic and splenic atrophy in newborn mice. Previously we showed that the YN strain contains three distinct plaque-type variants, LT, SC, and M. Of these, the M-type variant induced this fatal illness, whereas the other two variants induced hydrocephalus.
摘要
研究发现，给新生小鼠脑内接种副流感3病毒YN株可诱发一种急性致命疾病，其特征为胸腺和脾脏明显萎缩。此前我们发现，YN株包含三种不同的蚀斑型变体，即LT、SC和M。其中，M型变体诱发了这种致命疾病，而其他两种变体则诱发了脑积水。
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