[Effect of vitamin D3 and vitamin D3 sulfate on dental and bone tissues in the pig].

The repairing effects of vit. D3 and vit. D3 sulfate upon the hard tissues of vit. D3 deficient pigs have been studied using SEM and electron microprobe analyses. It was demonstrated that a vit. D3 therapy could balance lesions induced by vit. D3 deficiency. The effects of vit. D3 sulfate were not so clear. Results obtained were varying, sometimes similar to those obtained with vit. D3 but not always statistically significant. The rate of mineralization of dentine and bone was higher in animals having received vit. D3 and vit. D3 sulfate compared to the deficient group. In dentine and bone, the Ca/P ratio, thus the crystalline phases, wee modified, which was not the case for enamel and acellular cementum. It was shown that dentine and bone, which both include cells and cell processes in the calcified matrix, undergo similar modifications in the course of vit. D3 deficiencies and their therapy. On the contrary, enamel and acellular cementum in vit. D3 deficiency presented a lower rate of mineralization without any structural defects or modifications in Ca, P, Mg and F- ratios. Repair of lesions due to vit. D3 deficiencies by vit. D3 and, to a lower degree, by vit. D3 sulfate, concern, in order, bone, dentine, cementum and very little enamel.