• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Membrane effects of antiinflammatory agents. 1. Interaction of sulindac and its metabolites with phospholipid membrane, a magnetic resonance study.

作者信息

Fan S S, Shen T Y

出版信息

J Med Chem. 1981 Oct;24(10):1197-202. doi: 10.1021/jm00142a015.

DOI:10.1021/jm00142a015
PMID:6276543
Abstract

High-resolution proton NMR and spin-label ESR spectroscopies have been applied to examine the interaction of the nonsteroidal antiinflammatory drug sulindac (1) and its active sulfide metabolite (2) and inactive sulfone metabolite (3) with phospholipid membranes. Only weak interactions were observed with 1 and 3, but a strong interaction with 2 was indicated both by specific changes in the proton transverse relaxation rate (1/T2) of different substituents in 2 and by a unique shift in membrane transition temperature in the presence of 2 as measured by the ESR technique. Since the structural differences of these compounds are confined to a single polar substituent, i.e., the oxidation state of the sulfur atom, the strong interaction of the sulfide metabolite (2) with the neutral phospholipid membrane is ascribed to its high partition coefficient in the lipid membrane and its ability to penetrate into the lipid bilayer with the carboxyl group remaining at the polar membrane surface. As evidenced from the ESR spectra of two spin-labels, C5- and C12-doxylstearic acid, no significant change of the membrane fluidity was induced by the interaction of 2 with phospholipid vesicles.

摘要

相似文献

1
Membrane effects of antiinflammatory agents. 1. Interaction of sulindac and its metabolites with phospholipid membrane, a magnetic resonance study.
J Med Chem. 1981 Oct;24(10):1197-202. doi: 10.1021/jm00142a015.
2
Interactions of sulindac and its metabolites with phospholipid membranes: an explanation for the peroxidation protective effect of the bioactive metabolite.舒林酸及其代谢产物与磷脂膜的相互作用:对生物活性代谢产物过氧化保护作用的一种解释。
Free Radic Res. 2008 Jul;42(7):639-50. doi: 10.1080/10715760802270326.
3
Membrane effects of antiinflammatory agents. 2. Interaction of nonsteroidal antiinflammatory drugs with liposome and purple membranes.
J Med Chem. 1981 Oct;24(10):1202-11. doi: 10.1021/jm00142a016.
4
Effect of dimethyl sulfoxide on sulindac disposition in rats.
Drug Metab Dispos. 1981 Nov-Dec;9(6):499-502.
5
Physical studies on membrane lipids of Bacillus stearothermophilus temperature and calcium effects.嗜热脂肪芽孢杆菌膜脂的物理研究:温度和钙的影响
Arch Biochem Biophys. 1991 Aug 15;289(1):167-79. doi: 10.1016/0003-9861(91)90457-t.
6
Interaction of bee venom melittin with zwitterionic and negatively charged phospholipid bilayers: a spin-label electron spin resonance study.蜂毒溶血肽与两性离子及带负电荷的磷脂双层的相互作用:一项自旋标记电子自旋共振研究
Biophys J. 1997 Feb;72(2 Pt 1):767-78. doi: 10.1016/s0006-3495(97)78711-3.
7
Cholesterol-phospholipid interaction in membranes. 1. Cholestane spin-label studies of phase behavior of cholesterol-phospholipid liposomes.膜中胆固醇 - 磷脂的相互作用。1. 胆固醇 - 磷脂脂质体相行为的胆甾烷自旋标记研究。
Biochemistry. 1982 Aug 3;21(16):3821-30. doi: 10.1021/bi00259a016.
8
Electron Spin Resonance Evaluation of Buccal Membrane Fluidity Alterations by Sodium Caprylate and L-Menthol.用辛酸钠和L-薄荷醇对颊膜流动性改变进行电子自旋共振评估。
Int J Mol Sci. 2021 Oct 2;22(19):10708. doi: 10.3390/ijms221910708.
9
Pharmacokinetics of graded oral doses of sulindac in man.
Arzneimittelforschung. 1984;34(2):226-9.
10
A conformational model for the action of general anesthetics at the membrane level. II. Experimental observations on the effects of anesthetics on lipid fluidity and lipid protein interactions.全身麻醉药在膜水平作用的构象模型。II. 麻醉药对脂质流动性和脂质-蛋白质相互作用影响的实验观察
Ital J Biochem. 1978 Nov-Dec;27(6):401-30.

引用本文的文献

1
Targeting the Multiple Physiologic Roles of VDAC With Steroids and Hydrophobic Drugs.用类固醇和疏水药物靶向电压依赖性阴离子通道的多种生理作用。
Front Physiol. 2020 May 7;11:446. doi: 10.3389/fphys.2020.00446. eCollection 2020.
2
Novel γ-secretase enzyme modulators directly target presenilin protein.新型 γ-分泌酶酶调节剂直接靶向早老素蛋白。
J Biol Chem. 2011 Oct 28;286(43):37181-6. doi: 10.1074/jbc.C111.276972. Epub 2011 Sep 6.
3
Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.
β淀粉样蛋白 42 肽(Abeta42)降低化合物直接与 Abeta 结合,并干扰淀粉样前体蛋白(APP)跨膜二聚化。
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14597-602. doi: 10.1073/pnas.1003026107. Epub 2010 Aug 2.