Mizuno K, Gotoh M, Fukuchi S
Tohoku J Exp Med. 1981 Oct;135(2):217-8. doi: 10.1620/tjem.135.217.
The effect of sodium intake on angiotensin-converting enzyme activity in five areas of the brain (the cerebral cortex, midbrain, striatum, thalamus and hypothalamus) was studied in normotensive, spontaneously hypertensive and stroke-prone spontaneously hypertensive rats. The enzyme activity was significantly higher in the hypothalamus than in other areas of the brain of spontaneously hypertensive rats. Sodium intake resulted in a significant rise of the enzyme activity in the midbrain of spontaneously hypertensive rats and also in the midbrain and the striatum of stroke-prone spontaneously hypertensive rats. In normotensive rats, however, there was no significant difference in the enzyme activity in any area of brain between the control and the salt-treated group. It is likely therefore that a high circulating sodium level increases angiotensin-converting enzyme content of the brain in spontaneously hypertensive rats, and it is suggested that the increased converting-enzyme activity may play a role in development of hypertension induced by sodium loading.
在正常血压大鼠、自发性高血压大鼠和易卒中型自发性高血压大鼠中，研究了钠摄入对大脑五个区域（大脑皮层、中脑、纹状体、丘脑和下丘脑）血管紧张素转换酶活性的影响。自发性高血压大鼠下丘脑的酶活性显著高于大脑其他区域。钠摄入导致自发性高血压大鼠中脑的酶活性显著升高，也导致易卒中型自发性高血压大鼠中脑和纹状体的酶活性显著升高。然而，在正常血压大鼠中，对照组和盐处理组之间大脑任何区域的酶活性均无显著差异。因此，循环钠水平升高可能会增加自发性高血压大鼠大脑中血管紧张素转换酶的含量，并且提示转换酶活性增加可能在钠负荷诱导的高血压发展中起作用。
