Roth S, Rister M, Sack H
Strahlentherapie. 1981 Dec;157(12):773-9.
A combined treatment with surgery, radiotherapy and chemotherapy is necessary for children with adenomyosarcomas. In order to reduce the side effects of the treatment, it seems reasonable to establish a therapy plan taking into consideration the risk of recurrences. Besides the classification of stages according to the N.W.T.S., the following factors should be considered: histologic findings, manifestations of the lymph nodes, number of tumor nodes, size of the adenomyosarcoma, and a rupture of the adenomyosarcoma. A postoperative polychemotherapy is sufficient for children of stage I presenting favorable histological findings. For the stages II and III, an irradiation of the tumor and the lymph outflow regions or the total abdomen with 24 Gy is recommendable in addition to chemotherapy. For stage IV, an irradiation of the lung up to 12 Gy in addition to chemotherapy has proved to be useful. A pre-operative radio- or chemotherapy is indicated especially in case of a great tumor volume and stage III and IV.
对于腺肌肉瘤患儿，手术、放疗和化疗联合治疗是必要的。为了减少治疗的副作用，考虑复发风险制定治疗方案似乎是合理的。除了根据西北肿瘤协作组（N.W.T.S.）进行分期外，还应考虑以下因素：组织学结果、淋巴结表现、肿瘤结节数量、腺肌肉瘤大小以及腺肌肉瘤破裂情况。对于组织学结果良好的Ⅰ期患儿，术后多药化疗就足够了。对于Ⅱ期和Ⅲ期，除化疗外，建议对肿瘤及淋巴引流区域或全腹进行24 Gy的照射。对于Ⅳ期，除化疗外，对肺部进行12 Gy的照射已被证明是有效的。特别是在肿瘤体积较大以及Ⅲ期和Ⅳ期的情况下，术前放疗或化疗是必要的。
