Bracken R B, Sutow W W, Jaffe N, Ayala A, Guarda L
Urology. 1982 Jan;19(1):55-60. doi: 10.1016/0090-4295(82)90047-4.
Preoperative chemotherapy was administered to 19 children with Wilms tumor judged clinically to be unresectable at M. D. Anderson Hospital between January 1, 1962, and September 1, 1980. After 2 to 4 doses of vincristine, marked reduction in tumor size occurred in 16 patients. After chemotherapy 16 tumors could be resected completely, another required irradiation to reduce the tumor, and only 2 tumors could not be excised. Pathologically the most dramatic changes occurred in the undifferentiated interstitial stroma, followed next by changes in the nodular blastema. Differentiated elements were apparently not affected. No serious complications were attributed to the preoperative drug treatment. This experience suggests that in selected instances preoperative chemotherapy can affectively facilitate the therapy of Wilms tumor.
1962年1月1日至1980年9月1日期间，在MD安德森医院，对19名临床判断为无法切除的肾母细胞瘤患儿进行了术前化疗。在给予2至4剂长春新碱后，16例患者的肿瘤大小明显缩小。化疗后，16个肿瘤可以完全切除，另一个需要放疗以缩小肿瘤，只有2个肿瘤无法切除。病理上，最显著的变化发生在未分化的间质基质中，其次是结节状胚基的变化。分化成分显然未受影响。术前药物治疗未导致严重并发症。这一经验表明，在某些情况下，术前化疗可以有效地促进肾母细胞瘤的治疗。
