Royet J P, Pager J
Behav Brain Res. 1982 Mar;4(3):251-62. doi: 10.1016/0166-4328(82)90003-1.
The contribution of ascending olfactory pathways in neophobia and learned aversion to the same food was investigated in male rats bearing lesions of both olfactory peduncles, or one olfactory peduncle and the opposite lateral olfactory tract or anterior limb of the anterior commissure. The animals were fed on usual stock diet (S) offered as a choice with novel vanilla food (V) on test days: during neophobia (N), then before and after aversive conditioning (Aa, At). Daily food intake was measured, and the preference was expressed as V/(V + S). Experiment 1 included a neophobia test, before aversive conditioning (3 mEq/kg LiCl, i.p.). In Experiment 2, aversion only was studied (0.9 mEq/kg). In the neophobia test, the preference ratio was 7% in unoperated controls, and 43-52% in the 3 lesioned groups. The same controls had preference ratios equal to 64% and 22%, before and after aversive learning. Similar drops were observed for any lesioned group in Expt. 1. The decrease was less obvious, although significant, in rats of Expt. 2 with asymmetric lesions; those with both olfactory peduncles cut through maintained the same preference ratio (48%) before and after LiCl treatment. The data are interpreted assuming that: (1) lateral olfactory tract and anterior commissure both contribute to information processing in neophobia and aversion; (2) olfactory cues subserve neophobia prepotently; and (3) one cannot account for the sensory determinism of neophobia and aversion calling for a single mechanism.
在雄性大鼠中，研究了嗅觉上升通路在新异恐惧症和对同一种食物的习得性厌恶中的作用。这些大鼠的双侧嗅球、一侧嗅球与对侧外侧嗅束或前连合前肢受损。在测试日，给动物提供常规饲料（S），并让它们在新颖的香草味食物（V）之间进行选择：在新异恐惧症阶段（N），然后在厌恶条件反射前后（Aa，At）。测量每日食物摄入量，并将偏好表示为V/(V + S)。实验1包括在厌恶条件反射前（腹腔注射3 mEq/kg LiCl）进行的新异恐惧症测试。在实验2中，仅研究厌恶反应（0.9 mEq/kg）。在新异恐惧症测试中，未手术对照组的偏好率为7%，而3个损伤组的偏好率为43 - 52%。相同的对照组在厌恶学习前后的偏好率分别为64%和22%。在实验1中，任何损伤组都观察到了类似的下降。在实验2中，不对称损伤的大鼠中下降不太明显，尽管有统计学意义；双侧嗅球被切断的大鼠在LiCl处理前后保持相同的偏好率（48%）。对数据的解释基于以下假设：（1）外侧嗅束和前连合都对新异恐惧症和厌恶中的信息处理有贡献；（2）嗅觉线索在新异恐惧症中起主要作用；（3）不能用单一机制来解释新异恐惧症和厌恶的感觉决定因素。
