Porsius A J, Lambrecht G, Moser U, Mutschler E
Eur J Pharmacol. 1982 Jan 8;77(1):49-52. doi: 10.1016/0014-2999(82)90534-9.
Upon their simultaneous administration into the left and right vertebral artery of the cat, 2 x 30 micrograms isoarecaidine propyl ester (IAPE) and 2 x 30 micrograms isoguvacine propyl ester (IGPE) induce hypotension and bradycardia. These effects were antagonized by (+)-bicuculline or picrotoxin. IAPE is rapidly hydrolyzed by cat brain tissue in vivo. It is suggested that both IAPE and IGPE are prodrugs and that the corresponding carboxylic acids are GABA agonists and responsible for the cardiovascular effects evoked.
当将2×30微克异槟榔次碱丙酯（IAPE）和2×30微克异古豆碱丙酯（IGPE）同时注入猫的左、右椎动脉时，会引起低血压和心动过缓。这些作用可被（+）-荷包牡丹碱或印防己毒素拮抗。IAPE在体内能被猫脑组织迅速水解。提示IAPE和IGPE均为前体药物，相应的羧酸是GABA激动剂，并负责引发的心血管效应。
