Kajiyama H, Obara K, Nomura Y, Segawa T
Eur J Pharmacol. 1982 Jan 8;77(1):75-7. doi: 10.1016/0014-2999(82)90540-4.
An analysis of Hofstee plots of specific [3H]dihydroalprenolol ([3H]DHA) binding in the presence of various concentrations of practolol showed that KD and Bmax in beta 1-subtype adrenoceptors were 19.2-fold lower and 2.76-fold higher than those in beta 2-subtype in adult rat hearts, respectively. Neonatal treatment with 6-hydroxydopa produced a significant increase only in Bmax in beta 1-adrenoceptors without changing Bmax and KD in beta 2-receptors. "Up' regulation in the density of beta 2-type of adrenoceptors seems to be caused by the 6-hydroxydopa-induced sympathetic lesion.
在不同浓度的心得宁存在下，对特定的[3H]二氢心得舒（[3H]DHA）结合的霍夫斯泰曲线分析表明，成年大鼠心脏中β1 - 亚型肾上腺素能受体的解离常数（KD）和最大结合容量（Bmax）分别比β2 - 亚型低19.2倍和高2.76倍。新生期用6 - 羟基多巴处理仅使β1 - 肾上腺素能受体的Bmax显著增加，而β2 - 受体的Bmax和KD未改变。β2 - 型肾上腺素能受体密度的“上调”似乎是由6 - 羟基多巴诱导的交感神经损伤引起的。
