Barrett R J, Lokhandwala M F
Eur J Pharmacol. 1982 Jan 8;77(1):79-83. doi: 10.1016/0014-2999(82)90541-6.
The effect of pergolide, a dopaminergic ergoline, on cardiac sympathetic neurotransmission was examined in pentobarbital-anesthetized dogs. Positive chronotropic responses to right postganglionic cardioaccelerator nerve stimulation were significantly reduced following infusion of pergolide, 1.25 microgram/kg per min for 10 min, whereas positive chronotropic responses to exogenous norepinephrine were unchanged. Pretreatment with sulpiride but not with yohimbine completely antagonized the inhibitory effect of pergolide. These results demonstrate that pergolide inhibits sympathetic neurotransmission to the heart by a specific activation of presynaptic dopamine receptors.
在戊巴比妥麻醉的犬中研究了多巴胺能麦角灵培高利特对心脏交感神经传递的影响。在以每分钟1.25微克/千克的速度输注培高利特10分钟后，对右侧节后心脏加速神经刺激的正性变时反应显著降低，而对外源性去甲肾上腺素的正性变时反应未改变。用舒必利而非育亨宾预处理可完全拮抗培高利特的抑制作用。这些结果表明，培高利特通过特异性激活突触前多巴胺受体来抑制心脏的交感神经传递。
