大鼠阴道内给予含壬苯醇醚-9的避孕乳膏的致畸学研究。

Teratology study of intravaginally administered nonoxynol-9-containing contraceptive cream in rats.

作者信息

Abrutyn D, McKenzie B E, Nadaskay N

出版信息

Fertil Steril. 1982 Jan;37(1):113-7. doi: 10.1016/s0015-0282(16)45988-1.

Abstract

Pregnant Long-Evans Hooded rats were intravaginally administered nonoxynol-9, a non-ionic surfactant used as a spermicidal agent in Delfen Contraceptive Cream (Ortho Pharmaceutical Corporation, Raritan, N.J.) at dosages of 4 or 40 mg/kg/day (2 and 20 times the clinical usage) on days 6 through 15 of gestation. Untreated, vehicle and sham control groups were also incorporated into the study protocol. No meaningful differences were observed between the treated and control groups in maternal toxicity, gross and microscopic appearance of vagina, maternal reproductive parameters, fetal toxicity, and the incidence of visceral and skeletal malformations.

摘要

将妊娠的长 Evans 戴帽大鼠在妊娠第 6 至 15 天经阴道给予壬苯醇醚 -9，这是一种非离子表面活性剂，在 Delfen 避孕乳膏（新泽西州拉里坦市 Ortho 制药公司）中用作杀精剂，剂量为 4 或 40 mg/kg/天（临床用量的 2 倍和 20 倍）。未处理组、赋形剂组和假手术对照组也纳入了研究方案。在母体毒性、阴道大体和微观外观、母体生殖参数、胎儿毒性以及内脏和骨骼畸形发生率方面，治疗组和对照组之间未观察到有意义的差异。