Serebrov V Iu, Vasil'ev N V, Udintsev N A
Biull Eksp Biol Med. 1982 Feb;93(2):46-8.
A number of modern research methods were used in experiments on 220 white rats to examine thyroid function at varying times after single immunization with typhoid vaccine. It was found that on the 1st and 2nd days of the observation period, only cAMP level of the thyroid parenchyma decreases. Three, four and seven days following immunization, thyroid function is drastically reduced, which manifests by a decrease in 131I uptake by the thyroid gland. Also decreased were the conversion ratio, the levels of thyroxine and triiodothyronine in blood serum and incorporation of labeled thyroxin by the heart, liver and spleen. During the productive phase of the immunogenesis (days 10, 15, 20 and 25), all the test indicators considerably increase. The phases of the reaction obtained seem likely to be a consequence of reciprocal relationship between the thyroid and sympathoadrenal systems (the inductive period), as well as by the feedback effect (the productive period of antibody formation). The reaction of thyroid function to immunization is regarded as a component of non-specific adaptation response of the body to an extreme irritant, that provides for metabolic reconstruction necessary for the synthesis of antibodies and formation of immune lymphocyte populations.
在对220只白鼠进行的实验中，采用了多种现代研究方法，以检测在单次接种伤寒疫苗后的不同时间甲状腺功能的变化。结果发现，在观察期的第1天和第2天，仅甲状腺实质的环磷酸腺苷（cAMP）水平下降。免疫接种后的第3、4和7天，甲状腺功能急剧降低，表现为甲状腺对131I摄取量减少。血清中甲状腺素和三碘甲状腺原氨酸的转化率、水平以及心脏、肝脏和脾脏对标记甲状腺素的摄取也均下降。在免疫发生的效应期（第10、15、20和25天），所有检测指标均显著升高。所获得的反应阶段似乎是甲状腺与交感肾上腺系统之间相互关系（诱导期）以及反馈效应（抗体形成效应期）的结果。甲状腺功能对免疫接种的反应被视为机体对极端刺激的非特异性适应反应的一个组成部分，它为抗体合成和免疫淋巴细胞群体形成所需的代谢重建提供支持。
