Katoh T, Endoh N, Takamizawa H
Nihon Sanka Fujinka Gakkai Zasshi. 1982 Apr;34(4):511-20.
The recurrence of the patients who had obtained remissions once was studied and the standard of remission was reassessed. The comparison of the titers of hCG ranged the LH levels was studied by means of some methods of measurement. 1) During 7 years, from 1973-1979, 141 patients with trophoblastic disease in Chiba University Hospital were treated. The remission rate was 92.2% (130/141), the recurrence rate was 6.2% (8/130). In the high risk group, the recurrence rate was 23.1% (6/26), in the low risk, it was 1.9% (2/104). Four of 8 with recurrence were died, 4 (2 high risk and 2 low risk) obtained remissions again. 2) The mean HCG titers of patients with recurrence were 29.5 +/- 23.5 IU/L (HAR), 13.7 +/- 6.4 mIU/ml (HCG-RIA), 1.5 +/- 0.7 ng/ml (HCG-beta RIA) and that of patients with remission were 13.8 +/- 13.0 IU/L, 11.3 +/- 4.1 mIU/ml, 1.0 +/- 0.6 ng/ml, respectively. 3) The 2 patients whose HCG titers indicated all negative followed the recurrences. The HCG beta titers of the patients who were extirpated their bilateral ovaries indicated rather high in spite of getting their remissions. 4) The essential standard of remission was the equanimity of the HCG titers around the negative levels without disturbance by LH or other substances for a while. But it is not enough for a remission.
对曾获得缓解的患者的复发情况进行了研究，并重新评估了缓解标准。通过一些测量方法研究了人绒毛膜促性腺激素（hCG）滴度与促黄体生成素（LH）水平的比较。1）1973年至1979年的7年间，千叶大学医院治疗了141例滋养细胞疾病患者。缓解率为92.2%（130/141），复发率为6.2%（8/130）。高危组的复发率为23.1%（6/26），低危组为1.9%（2/104）。8例复发患者中有4例死亡，4例（2例高危和2例低危）再次获得缓解。2）复发患者的平均hCG滴度分别为29.5±23.5国际单位/升（血凝抑制反应法）、13.7±6.4毫国际单位/毫升（放射免疫分析法）、1.5±0.7纳克/毫升（β-放射免疫分析法），缓解患者的平均hCG滴度分别为13.8±13.0国际单位/升、11.3±4.1毫国际单位/毫升、1.0±0.6纳克/毫升。3）2例hCG滴度均呈阴性的患者出现了复发。双侧卵巢被切除的患者，尽管已获得缓解，但其hCGβ滴度仍相当高。4）缓解的基本标准是hCG滴度在阴性水平附近保持稳定，一段时间内不受LH或其他物质的干扰。但这对于缓解来说还不够。
