Ratzenhofer M
Langenbecks Arch Chir. 1981;355:87-97. doi: 10.1007/BF01286819.
During the last 22 years in Styria lung cancers, as revealed in autopsies, have increased in men by 9% and in women by 173%. In women undifferentiated carcinomas have been found six times as frequently as previously. The histological findings of mixed types of carcinomas with confusing cytology are presented: metastasizing squamous carcinoma with a survival time of 14 years and lung cancer developing in the upper lobe 35 years after being present in the lower lobe. In oat-cell carcinomas, certain structures suggest they originate from endocrine cells of the bronchial epithelium. This was also proven in bronchial peptide-producing microcarcinoidosis (tumorlets) and in carcinoids. At the same time, there are neuroendocrine contacts between tumors and nerves similar to carcinoids of the appendix and rectum.
在施蒂利亚州过去的22年里,尸检显示男性肺癌增加了9%,女性肺癌增加了173%。在女性中,未分化癌的发现频率是以前的六倍。本文介绍了细胞学表现令人困惑的混合型癌的组织学发现:转移性鳞状癌存活时间为14年,下叶出现肺癌35年后上叶又发生肺癌。在燕麦细胞癌中,某些结构表明它们起源于支气管上皮的内分泌细胞。这在产生肽的支气管微小类癌(微瘤)和类癌中也得到了证实。与此同时,肿瘤与神经之间存在神经内分泌联系,类似于阑尾和直肠类癌。