Ferreira S H, Lorenzetti B B
Prostaglandins. 1981 May;21(5):789-92. doi: 10.1016/0090-6980(81)90235-5.
Prostaglandin E2, prostacyclin and Db-cAMP injected into the rat paw induce hyperalgesia. This hyperalgesic effect of the prostaglandins but not of Db-CAMP was blocked by pre-treatment of the animals with cycloheximide. Prostaglandin hyperalgesia thus seems to be dependent on the triggering of some metabolic process which enhances the effects of physical or chemical stimuli.