Tabor E, Gerety R J, Smallwood L A, Barker L F
J Immunol. 1976 Nov;117(5 Pt.2):2038-40.
Antibody to the y determinant of hepatitis B surface antigen (HBsAg) was induced in a chimpanzee chronically infected with hepatitis B virus and circulating HBsAg subtype adw. The chimpanzee was immunized with purified preparations of HBsAg subtypes adw and ayw. Six weeks after immunization, antibody to HBsAg (anti-HBs) specific for the y determinant, appeared. No change occurred in titers of HBsAg or antibody to hepatitis B core antigen (anti-HBc) and "e" antigen remained detectable. The circulating HBsAg subtype adw remained present despite the persistence of anti-y for greater than 8 months.
在一只慢性感染乙型肝炎病毒且循环中有乙肝表面抗原（HBsAg）adw亚型的黑猩猩体内诱导产生了针对乙肝表面抗原y决定簇的抗体。用纯化的HBsAg adw和ayw亚型制剂对这只黑猩猩进行免疫。免疫六周后，出现了针对y决定簇的乙肝表面抗原抗体（抗-HBs）。HBsAg或乙肝核心抗原抗体（抗-HBc）的滴度没有变化，“e”抗原仍可检测到。尽管抗-y持续存在超过8个月，但循环中的HBsAg adw亚型仍然存在。
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