Kojiro M, Kawano Y, Kawasaki H, Nakashima T, Ikezaki H
Cancer. 1982 May 15;49(10):2161-4. doi: 10.1002/1097-0142(19820515)49:10<2161::aid-cncr2820491029>3.0.co;2-m.
A 64-year-old man developed hepatic angiosarcoma, and combined hepatocellular and cholangiocarcinoma, 36 years after Thorotrast administration. The patient presented with a large mass in the right upper quadrant. His serum alpha-fetoprotein increased from 800 ng/ml to 51.2 micrograms/ml, and liver biopsy disclosed hepatocellular carcinoma. At autopsy, the liver had two different malignant neoplasms; angiosarcoma and combined hepatocellular and cholangiocarcinoma. Metastases of angiosarcoma to both lungs and of cholangiocarcinoma to periaortic lymph nodes were also seen. Interestingly, some neoplastic cells of angiosarcoma exhibited globular hyaline inclusions, which were Periodic-Acid-Schiff reaction positive and diastase-resistant.
一名64岁男性在注射钍胶体36年后发生了肝血管肉瘤，并合并肝细胞癌和胆管癌。患者右上腹出现一个大肿块。他的血清甲胎蛋白从800 ng/ml升至51.2μg/ml，肝脏活检显示为肝细胞癌。尸检时，肝脏有两种不同的恶性肿瘤；血管肉瘤和肝细胞癌合并胆管癌。还发现血管肉瘤转移至双肺，胆管癌转移至主动脉旁淋巴结。有趣的是，血管肉瘤的一些肿瘤细胞呈现球形透明包涵体，对高碘酸-希夫反应呈阳性且耐淀粉酶。
