Norstedt G
Endocrinology. 1982 Jun;110(6):2107-12. doi: 10.1210/endo-110-6-2107.
Human GH (hGH) increased hepatic PRL and estrogen receptors in hypophysectomized (Hx) female rats after continuous infusion of the hormone (5 micrograms/h) using osmotic minipumps, but not after the infrequent administration of the same daily dose (120 micrograms) of the hormone by sc injections (60 micrograms/12 h). The effects of hGH on body weight (an increase) and tibial epiphyseal zones (a widening) were observed regardless of the mode of hGH administration. Thus, it would seem as if the mode of administration of hGH is of importance for the type of biological effect exerted by the hormone. Furthermore, rGH was effective in increasing both PRL and estrogen receptors in the liver of Hx ovariectomized (HxOx) rats, whereas rat PRL (rPRL) was much less efficient. Finally, rat GH (rGH) suppressed the concentration of a nonreceptor estrogen-binding protein in the liver of HxOx rats; the protein occurred at a low concentration in Ox rats and was markedly increased after hypophysectomy rPRL was inefficient in modulating the concentration of estrogen-binding protein. Thus, rGH, but not rPRL, seems to regulate both sexually differentiated (PRL receptors and estrogen-binding protein) and sexually nondifferentiated (estrogen receptor) functions in the rat liver. The mechanism behind this dual effect of rGH is obscure, but may possibly be related to the presence of isohormones of rGH with different effects on the liver.
使用渗透微型泵持续输注激素（5微克/小时）后，人生长激素（hGH）可增加垂体切除（Hx）雌性大鼠肝脏中的催乳素（PRL）和雌激素受体，但通过皮下注射（60微克/12小时）不频繁给予相同日剂量（120微克）的激素时则不会增加。无论hGH的给药方式如何，均可观察到其对体重（增加）和胫骨骨骺区（增宽）的影响。因此，hGH的给药方式似乎对该激素所产生的生物学效应类型很重要。此外，重组生长激素（rGH）可有效增加垂体切除卵巢切除（HxOx）大鼠肝脏中的PRL和雌激素受体，而大鼠催乳素（rPRL）的效果则差得多。最后，大鼠生长激素（rGH）可抑制HxOx大鼠肝脏中一种非受体雌激素结合蛋白的浓度；该蛋白在卵巢切除（Ox）大鼠中的浓度较低，垂体切除后明显升高，rPRL在调节雌激素结合蛋白浓度方面效率低下。因此，rGH而非rPRL似乎在调节大鼠肝脏中性别分化（PRL受体和雌激素结合蛋白）和性别未分化（雌激素受体）的功能。rGH这种双重作用背后的机制尚不清楚，但可能与对肝脏有不同作用的rGH同工激素的存在有关。
