在动物模型中使用细胞膜相关抗原的单纯疱疹疫苗。
Herpes simplex vaccine using cell membrane associated antigen in an animal model.
作者信息
Thornton B, Griffiths J B, Walkland A
出版信息
Dev Biol Stand. 1981;50:201-6.
PMID:6281105
Abstract
Vesicles of plasma membrane, containing no detectable live virus, were prepared by treatment of Herpes simplex virus type 2 (HSV-2) infected Vero cells with dithiothreitol and formaldehyde. These preparations proved to be antigenic on injection into guinea-pigs and also protected these animals against intravaginal challenge with HSV-2.
摘要
通过用二硫苏糖醇和甲醛处理感染了2型单纯疱疹病毒（HSV - 2）的非洲绿猴肾细胞（Vero细胞），制备出不含可检测到的活病毒的质膜囊泡。将这些制剂注射到豚鼠体内后，证明具有抗原性，并且还能保护这些动物免受HSV - 2的阴道内攻击。
Zotero 插件