Acumentin是巨噬细胞中的一种蛋白质，它覆盖在肌动蛋白丝的“尖”端。

Acumentin, a protein in macrophages which caps the "pointed" end of action filaments.

作者信息

Southwick F S, Hartwig J H

出版信息

Nature. 1982 May 27;297(5864):303-7. doi: 10.1038/297303a0.

Abstract

Macrophages have a calcium-insensitive protein which binds to and inhibits monomer addition at the "pointed" end of actin filaments labelled with heavy meromyosin. This protein, in concert with calcium-sensitive proteins already shown to bind the "barbed" end of filaments, can lead to complete control of actin filament length in the cytoplasm. The blocking of actin filament ends in low as well as high calcium concentrations would prevent treadmilling in living cells.

摘要

巨噬细胞有一种对钙不敏感的蛋白质，它能结合并抑制肌动蛋白丝“尖端”（用重酶解肌球蛋白标记）的单体添加。这种蛋白质与已被证明能结合肌动蛋白丝“刺端”的钙敏感蛋白协同作用，可完全控制细胞质中肌动蛋白丝的长度。在低钙和高钙浓度下对肌动蛋白丝末端的阻断会阻止活细胞中的肌动蛋白丝踏车行为。