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滋养细胞肿瘤中胎盘蛋白5的免疫组织化学检测

Immunohistochemical demonstration of placental protein 5 in trophoblastic tumours.

作者信息

Lee J N, Wahlström T, Seppälä M, Salem H T, Ouyang P C, Chard T

出版信息

Placenta. 1982 Jan-Mar;3(1):67-70. doi: 10.1016/s0143-4004(82)80019-2.

DOI:10.1016/s0143-4004(82)80019-2
PMID:6281754
Abstract

An immunoperoxidase technique was used for the detection of placental protein 5 (PP5) in tissue specimens from trophoblastic tumours. PP5 was detected in all of 15 cases of hydatidiform mole, in two out of six destructive moles and in one of seven choriocarcinomas. Though the biological importance of PP5 is not clear, its association with inactivation of plasmin suggests a role in the control of placental invasiveness.

摘要

采用免疫过氧化物酶技术检测滋养层肿瘤组织标本中的胎盘蛋白5(PP5)。在15例葡萄胎、6例侵蚀性葡萄胎中的2例以及7例绒毛膜癌中的1例中检测到了PP5。虽然PP5的生物学重要性尚不清楚,但其与纤溶酶失活的关联表明它在控制胎盘侵袭性方面发挥作用。

相似文献

1
Immunohistochemical demonstration of placental protein 5 in trophoblastic tumours.滋养细胞肿瘤中胎盘蛋白5的免疫组织化学检测
Placenta. 1982 Jan-Mar;3(1):67-70. doi: 10.1016/s0143-4004(82)80019-2.
2
Placental protein 5 in gestational trophoblastic disease: localization and circulating levels.
Am J Obstet Gynecol. 1982 Oct 15;144(4):396-401. doi: 10.1016/0002-9378(82)90243-5.
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Placenta-associated plasma protein-A (PAPP-A, SP4) in trophoblastic tumours.滋养层肿瘤中的胎盘相关血浆蛋白A(PAPP-A,SP4)
Acta Pathol Microbiol Scand A. 1981 Jan;89(1):65-6. doi: 10.1111/j.1699-0463.1981.tb00189.x.
4
[Pregnancy and placental proteins (SP1, HCG, PP5, alpha 2-PAG) in trophoblastic tumor diseases].[滋养层细胞瘤疾病中的妊娠与胎盘蛋白(SP1、人绒毛膜促性腺激素、PP5、α2 - 妊娠相关糖蛋白)]
Orv Hetil. 1981 Oct 25;122(43):2650-4.
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Detection of pregnancy specific beta1-glycoprotein in formalin-fixed tissues.在福尔马林固定组织中检测妊娠特异性β1-糖蛋白
J Clin Pathol. 1977 Jan;30(1):19-23. doi: 10.1136/jcp.30.1.19.
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Comparative study of placental protein 19, human chorionic gonadotrophin and pregnancy-specific beta 1-glycoprotein as immunohistochemical markers for extravillous trophoblast in pregnancy and trophoblastic disease.胎盘蛋白19、人绒毛膜促性腺激素和妊娠特异性β1-糖蛋白作为妊娠和滋养细胞疾病中外周滋养细胞免疫组化标志物的比较研究。
Histochemistry. 1989;93(2):167-73. doi: 10.1007/BF00315971.
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Circulating placental proteins (hCG, SP1 and PP5) in trophoblastic disease.
Br J Obstet Gynaecol. 1982 Jan;89(1):69-72. doi: 10.1111/j.1471-0528.1982.tb04639.x.
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Immunologic and biological properties and clinical significance of placental proteins PP5 and PP12.
Ann N Y Acad Sci. 1983;417:368-82. doi: 10.1111/j.1749-6632.1983.tb32879.x.
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p57(KIP2) immunohistochemical staining of gestational trophoblastic tumours does not identify the type of the causative pregnancy.妊娠滋养细胞肿瘤的p57(KIP2)免疫组化染色无法确定致病妊娠的类型。
Histopathology. 2004 Aug;45(2):135-41. doi: 10.1111/j.1365-2559.2004.01904.x.
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Circulating levels and tissue localization of placental protein five (PP5) in pregnancy and trophoblastic disease: absence of PP5 expression in the malignant trophoblast.胎盘蛋白5(PP5)在妊娠及滋养细胞疾病中的循环水平和组织定位:恶性滋养细胞中PP5表达缺失
Int J Cancer. 1979 Jul 15;24(1):6-10. doi: 10.1002/ijc.2910240103.

引用本文的文献

1
Advances in pathology and immunocytochemistry.病理学与免疫细胞化学的进展
J R Soc Med. 1985;78 Suppl 6(Suppl 6):9-18.