滋养细胞肿瘤中胎盘蛋白5的免疫组织化学检测
Immunohistochemical demonstration of placental protein 5 in trophoblastic tumours.
作者信息
Lee J N, Wahlström T, Seppälä M, Salem H T, Ouyang P C, Chard T
出版信息
Placenta. 1982 Jan-Mar;3(1):67-70. doi: 10.1016/s0143-4004(82)80019-2.
PMID:6281754
Abstract
An immunoperoxidase technique was used for the detection of placental protein 5 (PP5) in tissue specimens from trophoblastic tumours. PP5 was detected in all of 15 cases of hydatidiform mole, in two out of six destructive moles and in one of seven choriocarcinomas. Though the biological importance of PP5 is not clear, its association with inactivation of plasmin suggests a role in the control of placental invasiveness.
摘要
采用免疫过氧化物酶技术检测滋养层肿瘤组织标本中的胎盘蛋白5（PP5）。在15例葡萄胎、6例侵蚀性葡萄胎中的2例以及7例绒毛膜癌中的1例中检测到了PP5。虽然PP5的生物学重要性尚不清楚，但其与纤溶酶失活的关联表明它在控制胎盘侵袭性方面发挥作用。
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