大鼠脑室内注射氨甲酰甲胆碱诱导湿狗样抖动。神经递质受体阻滞剂的拮抗作用。

Induction of wet dog shakes by intracerebroventricular bethanechol in rats. Antagonism by neurotransmitter receptor blockers.

作者信息

Turski L, Czuczwar J, Turski W, Kleinrok Z

出版信息

Pharmacology. 1982;24(2):105-10. doi: 10.1159/000137583.

Abstract

Bethanechol chloride, administered intracerebroventricularly, induces a characteristic wet dog shake (WDS) response in rats in a dose-related manner. WDS induced by bethanechol at the dose of 100 micrograms was antagonized by atropine, scopolamine and spiperone (muscarinic cholinergic and dopaminergic antagonists, respectively), whilst metergoline, methysergide, phentolamine, propranolol and bicuculline (serotonergic, alpha-adrenergic, beta-adrenergic and GABA-ergic antagonists) fail to inhibit this effect. The present experiments show that the shaking response may be produced by bethanechol, a potent muscarinic agent administered by the intracerebral route, and suggest that bethanechol-induced shaking behavior in rats may be a useful animal model for delineating agents with antimuscarinic activity.

摘要

脑室内注射氯化氨甲酰甲胆碱能以剂量相关的方式在大鼠中诱发典型的湿狗抖（WDS）反应。100微克剂量的氯化氨甲酰甲胆碱诱发的WDS可被阿托品、东莨菪碱和舒必利（分别为毒蕈碱胆碱能拮抗剂和多巴胺能拮抗剂）拮抗，而麦角新碱、甲基麦角新碱、酚妥拉明、普萘洛尔和荷包牡丹碱（5-羟色胺能、α-肾上腺素能、β-肾上腺素能和γ-氨基丁酸能拮抗剂）不能抑制这种效应。本实验表明，脑内途径给药的强效毒蕈碱剂氯化氨甲酰甲胆碱可产生抖颤反应，并提示氯化氨甲酰甲胆碱诱发的大鼠抖颤行为可能是一种用于描绘具有抗毒蕈碱活性药物的有用动物模型。