Ward D F, Gottesman M E
Science. 1982 May 28;216(4549):946-51. doi: 10.1126/science.6281888.
The bacteriophage lambda N gene product positively controls development by preventing termination of transcription at terminator sites critical to the sequential expression of phage genes. Many host transcription factors, including RNA polymerase, are involved in N gene action. Recent findings have shown that ribosomal proteins are also involved. The current understanding of how the N protein affects transcription termination is reviewed, and a possible model and current problems are discussed.
噬菌体λ N基因产物通过阻止在对噬菌体基因顺序表达至关重要的终止子位点处的转录终止来正向控制发育。许多宿主转录因子，包括RNA聚合酶，都参与N基因的作用。最近的研究结果表明核糖体蛋白也参与其中。本文综述了目前对N蛋白如何影响转录终止的理解，并讨论了一种可能的模型和当前存在的问题。
