汞对背眼鱼组织磷酸酶的体外效应以及乙二胺四乙酸（EDTA）和抗坏血酸（AA）在其恢复中的作用。

In vitro effect of mercury on tissue phosphatases of Notopterus notopterus and the role of EDTA and AA in their restoration.

作者信息

Verma S R, Jain M, Dalela R C

出版信息

Toxicol Lett. 1982 Jan;10(1):25-9. doi: 10.1016/0378-4274(82)90262-4.

PMID:6281944

Abstract

In vitro effects of four sublethal concentrations (0.10, 0.40, 0.80 and 1.20 micrograms) of mercury (hg) on acid, alkaline and glucose-6-phosphatases of liver, kidney and gills of Notopterus notopterus were studied. The maximum (80.76%) significant (P less than 0.001) inhibition in acid phosphatase of gills and minimum (36.66%) significant (P less than 0.05%) inhibition in alkaline phosphatase of kidney was observed at 1.20 microgram and 0.10 microgram Hg concentrations, respectively. EDTA and ascorbic acid (AA) restored the phosphatase activity to the greatest extent when administered with the Hg.

摘要

研究了四种亚致死浓度（0.10、0.40、0.80和1.20微克）的汞（Hg）对背鳍鱼肝脏、肾脏和鳃中酸性、碱性和葡萄糖-6-磷酸酶的体外影响。在1.20微克汞浓度下，鳃酸性磷酸酶的最大显著抑制率（80.76%，P<0.001），在0.10微克汞浓度下，肾脏碱性磷酸酶的最小显著抑制率（36.66%，P<0.05%）。当与汞一起给药时，乙二胺四乙酸（EDTA）和抗坏血酸（AA）能最大程度地恢复磷酸酶活性。