Staessen J, Fagard R, Lijnen P, Verschueren L J, Amery A
Acta Cardiol. 1982;37(1):1-9.
Eight hypertensive patients on chronic captopril treatment were studied: blood pressure, plasma converting enzyme activity (pCEA) and various components of plasma renin-angiotensin-aldosterone system were measured repeatedly, immediately before and up to 7 hours after the usual morning dose of captopril in 5 patients, or a matching placebo in 3 patients. In the patients, receiving a placebo no significant changes were observed over a 7 hour period in pCEA, plasma rénin activity (PRA), plasma angiotensin II (ANG II) plasma aldosterone (PAC) and blood pressure. In patients receive captopril (200 mg) pCEA rapidly decreased, reaching after 2 hours a minimum, corresponding to nearly 20 per cent of its reference value. Thereafter pCEA increased and after 7 hours remained only slightly depressed. Within the first hour after captopril intake a small but significant decrease of ANG II and PAC was observed, while PRA and blood pressure remained unchanged throughout the study period. A continuous low pCEA level is therefore not necessary to achieve a sustained blood pressure lowering effect during chronic captopril treatment.
对8名接受卡托普利长期治疗的高血压患者进行了研究：对5名患者在早晨常规剂量的卡托普利服用前及服用后长达7小时，对3名患者在服用匹配安慰剂前及服用后长达7小时，反复测量血压、血浆转换酶活性（pCEA）以及血浆肾素-血管紧张素-醛固酮系统的各种成分。服用安慰剂的患者在7小时内，pCEA、血浆肾素活性（PRA）、血浆血管紧张素II（ANG II）、血浆醛固酮（PAC）和血压均未观察到显著变化。服用卡托普利（200mg）的患者，pCEA迅速下降，2小时后降至最低，相当于其参考值的近20%。此后pCEA升高，7小时后仅略有降低。在服用卡托普利后的第一小时内，观察到ANG II和PAC有小幅但显著的下降，而PRA和血压在整个研究期间保持不变。因此，在卡托普利长期治疗期间，持续的低pCEA水平并非实现持续降压效果所必需。
