Snyder S, Karacan I, Salis P J
Curr Alcohol. 1981;8:159-66.
Thirty male alcoholic inpatients received in a random double-blind design placebo (P) or disulfiram 250 mg. (D) at bedtime in order to evaluate the effects of the latter on EEG-EOG sleep patterns. Subjects (S's) had no major medical illness and required no medication for 3 weeks prior to the study. There were 13 disulfiram S's and 17 placebo S's. The total REM time decreased significantly (p less than 0.05) in the D group. Total number of REM episodes decreased and latency to stage 1 REM increased in the disulfiram group. These results are characteristic of sleep patterns induced by the administration of catecholaminergics and opposite to those induced by catecholamine inhibiting agents.
30名男性酒精中毒住院患者按随机双盲设计，在睡前接受安慰剂（P）或250毫克双硫仑（D）治疗，以评估后者对脑电图 - 眼动图睡眠模式的影响。受试者在研究前3周无重大疾病且无需用药。有13名服用双硫仑的受试者和17名服用安慰剂的受试者。双硫仑组的快速眼动（REM）总时间显著减少（p小于0.05）。双硫仑组REM发作总数减少，1期REM潜伏期延长。这些结果是儿茶酚胺能药物给药诱导的睡眠模式的特征，与儿茶酚胺抑制剂诱导的睡眠模式相反。
