Freeman M L, Barnes W E, Gose E E, Klein G C, Kaplan E
Int J Nucl Med Biol. 1982;9(1):37-41. doi: 10.1016/0047-0740(82)90072-9.
A technique is presented for producing functional images derived from equilibrium gated blood pool studies as a means of diagnosing cardiac disease. These functional images are based on characteristics associated with the time variation of the count rate (the time domain) at each point of the image matrix rather than on the Fourier transform of the time-activity curve (the frequency domain) which has gained recent attention. As examples of this method, we present images which display the statistical variance of the time-activity curve at each pixel, corrected for the expected contribution due to random statistical fluctuation, and images which display the time at which each pixel reaches its minimum count value. Variance and time-to-minimum images are comparable to Fourier amplitude and phase images, respectively, and have been found to be useful in facilitating the diagnosis of wall motion abnormalities. A major advantage of time-domain analysis is the wide variety of features of potential clinical significance which may be investigated.
本文介绍了一种从平衡门控血池研究中生成功能图像的技术，作为诊断心脏病的一种手段。这些功能图像基于与图像矩阵每个点的计数率随时间变化（时域）相关的特征，而不是基于最近受到关注的时间 - 活性曲线的傅里叶变换（频域）。作为该方法的示例，我们展示了在每个像素处显示时间 - 活性曲线统计方差的图像（已针对随机统计波动的预期贡献进行校正），以及显示每个像素达到其最小计数值的时间的图像。方差图像和达到最小时间的图像分别与傅里叶幅度图像和相位图像相当，并且已被发现有助于诊断壁运动异常。时域分析的一个主要优点是可以研究具有潜在临床意义的各种各样的特征。
