Chrousos G P, Peck G L, Gross E G, Cutler G B, Loriaux D L
J Invest Dermatol. 1982 Jun;78(6):468-71. doi: 10.1111/1523-1747.ep12510160.
The adrenal secretion of androgens were examined in 9 women (ages 19-39 yr) with postadolescent idiopathic acne and compared to age and sex-matched normal controls. Plasma dehydroepiandrosterone (DHA), dehydroepiandrosterone sulfate (DHAS), androstenedione (delta 4-delta), cortisol, 17-hydroxyprogesterone, 11-deoxycortisol, and testosterone were measured by radioimmunoassay in the basal state and during a 48 hr ACTH infusion. The mean plasma and time-integrated plasma levels of the 3 adrenal androgens in patients with acne were 15-25% higher than normal controls, but the groups were not significantly different (p greater than .05). The plasma testosterone values, on the other hand, were similar in both groups. In addition, cortisol, 11-deoxycortisol and 17-hydroxyprogesterone basal plasma values and responses to ACTH in patients with acne were similar to the normal control values. These findings suggest that adrenal androgen secretion is at most mildly elevated in patients with idiopathic acne and is unlikely to be the sole cause of acne since many patients without acne have similar hormone levels. Increased sensitivity of the sebaceous gland to androgens or increased local metabolism of androgen hormones in the skin to potent androgen metabolites may offer alternative mechanisms for the pathogenesis of this disorder.
对9名患有青春期后特发性痤疮的女性（年龄19 - 39岁）的肾上腺雄激素分泌情况进行了检查，并与年龄和性别匹配的正常对照者进行了比较。通过放射免疫分析法在基础状态和48小时促肾上腺皮质激素（ACTH）输注期间测量血浆脱氢表雄酮（DHA）、硫酸脱氢表雄酮（DHAS）、雄烯二酮（δ4 - δ）、皮质醇、17 - 羟孕酮、11 - 脱氧皮质醇和睾酮。痤疮患者的3种肾上腺雄激素的平均血浆水平和血浆时间积分水平比正常对照者高15 - 25%，但两组之间无显著差异（p大于0.05）。另一方面，两组的血浆睾酮值相似。此外，痤疮患者的皮质醇、11 - 脱氧皮质醇和17 - 羟孕酮基础血浆值以及对ACTH的反应与正常对照值相似。这些发现表明，特发性痤疮患者的肾上腺雄激素分泌至多轻度升高，不太可能是痤疮的唯一原因，因为许多没有痤疮的患者也有相似的激素水平。皮脂腺对雄激素敏感性增加或皮肤中雄激素激素向强效雄激素代谢物的局部代谢增加可能为该疾病的发病机制提供替代机制。
