Turner R B, Hendley J O, Gwaltney J M
J Infect Dis. 1982 Jun;145(6):849-53. doi: 10.1093/infdis/145.6.849.
Specimens of nasal mucus were collected from 17 volunteers experimentally infected with rhinovirus and from 10 uninfected control subjects. Ciliated epithelial cells (CECs) were found in the nasal mucus of 16 of the infected volunteers but of none of the control subjects. The CECs were shown to contain rhinovirus antigen by indirect immunoperoxidase and fluorescent antibody staining. The pattern of CEC shedding was similar to the mean nasal symptom score pattern of the volunteers. However, the amount of CED shedding for an individual was not correlated with the severity of the symptoms. This finding suggests that the symptoms of a rhinovirus cold may be produced in part by processes that are independent of the severity of direct virus-induced damage to the epithelium.
从17名实验性感染鼻病毒的志愿者以及10名未感染的对照受试者中采集了鼻黏液样本。在16名感染志愿者的鼻黏液中发现了纤毛上皮细胞（CEC），而对照受试者的鼻黏液中未发现。通过间接免疫过氧化物酶和荧光抗体染色显示，CEC含有鼻病毒抗原。CEC脱落模式与志愿者的平均鼻部症状评分模式相似。然而，个体的CEC脱落量与症状严重程度无关。这一发现表明，鼻病毒感冒的症状可能部分由与病毒直接诱导的上皮损伤严重程度无关的过程产生。
